You probably won’t notice it since you hadn’t heard Waugh very much. Wesker spoke very little in Resident Evil 4 compared to the earlier games (aka Code Veronica and Resident Evil 0) that Waugh did the voice acting for.
D.C Douglas, the guy playing him in Resident Evil 5, is the same guy who did his voice in Umbrella Chronicles. So you’re fairly used to it. I will admit that Douglas does sound like he’s doing a better in Resident Evil 5 over Umbrella Chronicles, but I can still hear a difference. Douglas seems a bit higher pitched and he hasn’t really caught onto the character but that might change after I play Resident Evil 5.